Unstructured Region Variable Control of Ets - 1 DNA Binding by Multiple Phosphates

نویسنده

  • Miles A. Pufall
چکیده

, 142 (2005); 309 Science et al. Miles A. Pufall Unstructured Region Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): May 8, 2014 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/309/5731/142.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2005/06/27/309.5731.142.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/309/5731/142.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/309/5731/142.full.html#ref-list-1 , 15 of which can be accessed free: cites 30 articles This article 56 article(s) on the ISI Web of Science cited by This article has been http://www.sciencemag.org/content/309/5731/142.full.html#related-urls 43 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/molec_biol Molecular Biology subject collections: This article appears in the following

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Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.

Cell signaling that culminates in posttranslational modifications directs protein activity. Here we report how multiple Ca2+-dependent phosphorylation sites within the transcription activator Ets-1 act additively to produce graded DNA binding affinity. Nuclear magnetic resonance spectroscopic analyses show that phosphorylation shifts Ets-1 from a dynamic conformation poised to bind DNA to a wel...

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Miles A . Pufall , Phosphates in an Unstructured Region Variable Control of Ets - 1 DNA Binding by Multiple

http://www.sciencemag.org/cgi/content/full/309/5731/142 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/309/5731/142/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...

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تاریخ انتشار 2014